A consensus document for the clinical management of invasive fungal diseases


Invasive fungal diseases (IFDs) have become an importantcause of morbidity and mortality in immunosuppressedpatients, especially those with cancer and/or undergoinghematopoietic stem cell transplantation (HSCT).1,2Pediatric patients are equally susceptible to IFD com-pared to the adult population. However, there are relevantdifferences in the physiology, presence of comorbidities,pharmacokinetic and tolerance to antifungals, treatment reg-imens, underlying diseases evolution, populations at risk andprognosis of fungal infections. Therefore, the extrapolationof clinical practices consolidated in the adult population forchildren is sometimes inappropriate, making it necessary tocreate specific guidelines for the clinical management of IFDoptimized for pediatric patients assisted in our country. Inorder to propose algorithms for early diagnosis and best clin-ical management of IFDs in pediatric patients we reviewedall major multicenter studies designed to characterize theepidemiology of IFDs in children with cancer, as well as allrandomized clinical trials addressing empirical and targetedantifungal therapy. In the absence of randomized clinicaltrials, the best evidence available to support the recommen-dations were selected.

The main proposals of the INFOCU-LATAM are

  • To connect graduate students and health care workers interested in contributing to the development of local educational programs and guidelines for improving the early diagnosis and best clinical management of patients with fungal infections in our region
  • To promote and facilitate the conduction of collaborative multicenter studies delineated to understand the epidemiology of fungal infections in LATAM
  • To encourage advocacy initiatives necessary to convince health policy makers and hospital managers to provide better support to medical assistance to patients suffering from opportunistic and endemic fungal infections in our region


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  • ITS and TEF1α DNA Barcoding Databases
  • International Fungal Multi Locus Sequence Typing Database
  • Brazilian Society of Infectious Diseases